Mantle Cell International Prognostic Index (MIPI) not prognostic after R-hyper-CVAD

摘要

We read with interest the recent article by Hoster and colleagues from the German Low Grade Lymphoma Study Group (GL'SG) and the European Mantle Cell Lymphoma Network regarding a new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma.The MIPI was generated via a complex mathematical model. A simplified MIPI was subsequently-generated with a point score system (low risk: 0-3; intermediate risk: 4-5; high risk: 6-11). Although the authors stated a high concordance between the MIPI and simplified MEPI(weighted kappa 0.79), no overall survival curves nor median time of overall survival were provided for the simplified MIPI.1