Poliovirus vaccines: past, present, and future.

摘要

An important pediatric advance of the 1950s was the introduction of inactivated poliovirus vaccine (IPV), also known as the Salk vaccine. Inactivated poliovirus vaccine and its counterpart, oral poliovirus vaccine (OPV), also known as the Sabin vaccine, have saved hundreds of thousands of children and adults from contracting paralytic poliomyelitis, a major scourge of the mid-20th century. The celebration of the 100th anniversary of the Archives of Pediatrics and Adolescent Medicine provides a fitting opportunity to describe the effect of poliovirus vaccines during the past 50 years. This topic is particularly pertinent now because a major effort is underway to achieve the global eradication of wild poliovirus; however, the merits of this quest are being debated within the international health care community.