Characterization of Age and Polarity at Onset in Bipolar Disorder

摘要

2021 MAY 03 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - According to news reporting based on a preprint abstract, our journalists obtained the following quote sourced from medrxiv.org: "Background: Studying the phenotypic and genetic characteristics of age and polarity at onset (AAO, PAO) in bipolar disorder (BD) can provide new insights into disease pathology and facilitate the development of screening tools. Aims: To examine the genetic architecture of AAO and PAO and their association with BD disease characteristics. Methods: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (N=12977) and PAO (N=6773) were conducted in BD patients of 34 cohorts and a replication sample (N=2237). The association of onset with disease characteristics was investigated in two of these cohorts. "Results: Earlier AAO was associated with an increased risk of psychotic symptoms, suicidality, and fewer episodes.