Mapping the Korean Genome

摘要

Agilent Technologies, Inc has announced that scientists using an Agilent custom-designed comparative genomic hybridisation (CGH) array have sequenced the entire gene map of a Korean male. An international team led by researchers at Seoul National University published the results in Nature. The study, 'A highly annotated whole-genome sequence of a Korean individual', published in Nature, is the second Korean genome to be sequenced in recent months and the seventh complete human genome to be published in the past two years. "Through our studies, we have discovered that a much more accurate annotation of CNVs can be obtained for a given individual's genome when you combine data from high-resolution CGH experiments with whole-genome DNA sequencing data obtained using next-generation sequencing strategies," said Dr Charles Lee, Associate Professor, Harvard Medical School and Brigham & Women's Hospital, and one of the researchers of study. "In this case, we developed and used a customised, high-resolution CNV array set, manufactured by Agilent, containing 24 million oligonucleotide probes. It would be great to see similar approaches being used for comprehensively identifying CNVs in more individuals."