Pushing the Limits of Speed and Sensitivity in Drug Screening-an LC-MS solution

摘要

Comprehensive screening of biological samples in forensic toxicology and clinical research is not possible without powerful,highly sensitive instruments,which allow researchers to focus on the unambiguous identification of parent drugs and their corresponding metabolites.Gas chromatography mass spectrometry(GC-MS)is the traditional approach to toxicological drug screening using general unknown analysis-a broad screening method which screens for over 4000 substances-but has steadily been overshadowed by the rapid turnaround time,ease of use and high sensitivity of innovative LC-MS methods.