Effect of the dopamine D 3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters

摘要

The dopamine D 3 receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D 3 receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D 3 receptor manipulation does not modulate brain responses to food images in overweight and obese subjects.