Quantification of risk factors for herpes zoster: population based case-control study

摘要

STUDY QUESTION What are the effects of pre-existing clinical conditions on the risk of herpes zoster? SUMMARY ANSWER Conditions associated with increased risk of zoster included rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, chronic obstructive pulmonary disease, asthma, chronic kidney disease, type 1 diabetes, and depression. WHAT IS KNOWN AND WHATTHIS PAPER ADDS A range of clinical conditions have been postulated to be associated with an increased risk of zoster, raising the possibility that some people may be at high risk and could be targeted for vaccination. People with severely immunosuppressive conditions that are currently contraindications to vaccination were at the highest risk, emphasising the need for alternative risk reduction strategies in these groups. Participants and setting We used primary care records from the UK Clinical Practice Research Datalink (CPRD) to identify adults diagnosed as having herpes zoster and matched them to controls on age, sex, and general practice.