Synthesis of Indole Annulated [1,3]-Thiazaheterocycles and -macrocycles via Ring-Closing Metathesis

摘要

The diversity-oriented organic synthesis of novel indole annulated tricyclic [1,3]-thiazepino, thiazocino, thiazonino, thiazecino, thiazacycloundecino scaffolds with Z-selective and the symmetrical pentacyclic thiazaindole macrocyclic derivatives was demonstrated from 2-oxindole via ring-closing metathesis reaction as the key step in the presence of Grubbs’ catalyst and Lewis acid as an additive. This synthetic strategy provides an efficient way to access a library of novel tricyclic thiazaheterocycles and pentacyclic thiazamacrocycles.