’’One-Pot’’ Selective Synthesis of 3,4-Disubstituted Pyrroles and Benzo[f]indole-4,9-diones from 1,3-Indanedione, Aromatic Aldehydes and TosMIC

摘要

A variety of 3,4-disubstituted pyrroles and benzo[f]indole-4,9- diones have been selectively synthesized from readily available aromatic aldehydes, 1,3-Indanedione and tosylmethyl isocyanide (TosMIC) by a one-pot procedure in high yields. This methodology features operationally simple, practical with broad substrate scope and usage of easy to handle reagents. The one-pot sequential reactions proposed to proceeds through a tandem in situ generated chalcones and [3+2]- cycloaddition/ring cleavage or expansion process.