Synthesis of Novel 5-Substituted 6-Phenylpyrrolo[2, 3-d] pyrimidine Derivatives via One-pot Three-Component Reactions Under Catalyst-Free Condition

摘要

An efficient synthesis of some novel 5-subsituted 6-phenyl pyrrolo[2, 3-d]pyrimidine derivatives has been reported. The 5- substitution has been reported with indoles, 1H-pyrazol-5(4H)- one, and various heterocyclic/carbocyclic active methylene compounds. The synthesis has been achieved by one-pot three-component condensation of phenylglyoxal, 6-amino-1,3- dimethyluracil and substituted indoles/1H-pyrazol-5(4H)-one/ active methylene compounds in ethanol at reflux temperature under catalyst-free condition.