One-pot Three-component Synthesis of 4,4'-Arylidene-bis(3-methyl-pyrazolones) Derivatives in Water

摘要

Aldehydes,hydrazine and ethyl acetoacetate were used for the synthesis of 4,4'-arylidene-bis(3-methyl-pyrazolones) derivatives in water.In this green synthetic protocol,the solvent water itself catalyzed the reaction via hydrogen bonding,thus avoiding the use of any other catalyst to make the work up procedure easier.One-pot,environmental friendly and convenient are the highlights.