Strategies for Preventing Wrong Site, Wrong Procedure, Wrong Patient Surgery

摘要

In this article, Fournierand colleagues ask whether epilepsy-induced newborn cells could also be involved in cognitive impairments, a common comorbidity of TLE. This question is all the more relevant since the dentate gyrus plays a critical role in certain forms of memory (7) and newborn cells in epilepsy migrate, differentiate, and integrate abnormally in the dentate gyrus. In addition, a large number of studies—although there are some discrepancies—report alterations of memory performance after blockade of adult neurogenesis in non-epileptic rodents (3). Taken together, one would therefore expect that epilepsy-induced newborn cells would negatively impact dentate and memory function. While previous attempts have been made to test this hypothesis by blocking adult neurogenesis after SE (8), it is possible that the behavioral improvements observed could be caused directly by the treatment (here, valproate) and not the decreased neurogenesis. In this study, Fournier and colleagues used a different approach: Instead of blocking adult neurogenesis in their epilepsy model, they let newborn neurons develop freely and asked whether these neurons show signs of involvement in a memory task.