Antimicrobial and Cytotoxic Activity of Dihydrobenzofuran Neolignans

摘要

We have evaluated the antimicrobial activity of the dihydrobenzofuran neolignans (DBNs) 1 (()-trans-dehydrodicoumarate dimethyl ester), 2 (()-trans-dehydrodiferulate dimethyl ester, 3 (()-4-O-acetyl-trans-dehydrodicoumarate dimethyl ester), and 4 (()-4-O-acetyl-trans-dehydrodiferulate dimethyl ester) in terms of their minimum inhibitory concentration (MIC) values. We have also assessed the cytotoxicity of compounds 1-4 to V79 cells by the XTT assay. Compounds 1, 2, and 3 display moderate activity against Streptococcus mitis (MIC=400 mg/ml); compound 2 is also active against Lactobacillus casei (MIC=400 mg/ml). Additionally, compound 3 is moderately active against Aspergillus niger (MIC=125 mg/ml), A. fumigatus (MIC=500 mg/ml), and Mucor rouxii (MIC=250 mg/ml). Compounds 2 and 4 (IC50 > 400 mM), which have a methoxyl group at the aromatic ring, are less cytotoxic to V79 cells as compared to compounds 1 (IC50=232.007.33 mM) and 3 (IC50=67.97 3.45 mM).