Design, Synthesis and Anticancer Evaluation of Spiro [cyclohexane-1,1’-indene]-2,5-diene Analogues

摘要

A series of spirocyclohexaneindene-2,5-diene derivatives were synthesized from Spiro-Acid 5 which in turn was prepared from the easily accessible starting materials. The structure of spiroester 4 was thoroughly further confirmed by 2DNMR analysis. The synthesized compounds were screened for anticancer activity using murine melanoma cell line (B16F10), human breast cancer cell line (MCF-7) and human non-small cell lung carcinoma cell lines (A549). Among them 7f (tri fluorobenzene) and 7g (di fluorobenzene) analogues were the most active compounds in all three cell lines in the series.