Nanohybrid of ZnO-RGO as Heterogeneous Green Catalyst for the Synthesis of Medicinally Significant Indole Alkaloids and Their Derivatives

摘要

Nanohybrid of ZnO-RGO has been developed and employed as heterogeneous catalyst for the synthesis of medicinally significant organic scaffolds. In this work, the nanohybrid catalyst has been used for the one-pot synthesis of various indole alkaloids and their derivatives in good yields. Several molecules with different substitutions on heterocyclic ring have been synthesized to demonstrate the substrate scope and wide applicability of the catalyst. Indoles with both electron donating and electron withdrawing groups were found to be equally compatible and resulted in good yields. In addition, all the reactions have been performed in green reaction medium with ethanol and water as solvent and the absence of byproducts formed in the reaction makes the strategy Green and sustainable. Furthermore, the nanohybrid catalyst could be recycled multiple times without any significant loss in activity.