Triosephosphate Isomerase Inhibitors as Potential Drugs against Clostridium perfringens

摘要

Clostridium perfringes is a gram-positive anaerobic bacillus responsible for various infections in humans and the main cause of diseases such as gas gangrene, bacterial-associated diarrhea and food poisoning. Resistances to conventional medications have been identified in different strains of C. perfringens. Therefore, the development of new drugs against this bacterium is necessary. Here we use structural information of C. perfringens (CpTIM) and human (HsTIM) triosephosphate isomerase to look for specific CpTIM inhibitors by means of high-performance virtual detection. We selected nine com- pounds (C1 - C9) with high probability of CpTIM binding and low potential to bind to HsTIM, these compounds without report of specific use as an antibiotic. We determined that C2 and C4 decrease the activity of CpTIM by approximately 60%, while HsTIM is not primarily affected (10%). Therefore, C2 and C4 or their chemical derivatives should be further investigated as potential drugs against Clostridium perfringens.