Facile Engineering of Anti-Inflammatory Nanotherapies by Host-Guest Self-Assembly

摘要

Anti-inflammatory drugs have been broadly used for the treatment of different diseases,but many of them have low water-solubility,thereby leading to poor bioavailability and limited clinical benefits.Herein we report host-guest assembly of nanotherapies based on different hydrophobic anti-inflammatory drugs,in which β-cyclodextrin(β-CD)-conjugated polyethyleneimine(PEICDs)were used as host polymers.The spontaneous assembly and nanotherapy formation by PEICDs was first demonstrated using a nonsteroidal anti-inflammatory drug indomethacin,showing high loading efficiencies and loading contents.Besides inclusion interactions,hydrogenbonding and electrostatic forces are responsible for effective host-guest assembly.Moreover,this facile and robust approach can be generalized to other hydrophobic drugs.Due to the amorphous distribution of loaded drug molecules in nanotherapies,they can be rapidly and completely released,with the release rate relevant to the binding free energy between drug and β-CD.Accordingly,this host-guest assembly strategy is promising for developing effective anti-inflammatory nanotherapies.