Novel 1-O-Sulfono-α-d-Fructofuranosyl Sulfones as Possible Inhibitors of Human GnT-I Enzyme

摘要

Library of a new class of C-1 monosulfated saccharide derivatives derived from D-fructofuranose have been synthesized as potential GnT-I inhibitors. To increase stability of originally proposed thioglycosides, the compounds were oxi-dized to sulfones bearing three different aglycons; ethyl, 2-methyl propyl (isopropyl) and phenyl. Here we present molecular modelling, synthesis and biological assays of prepared compounds.