Facile One-Pot Synthesis of Magnetic Targeted Polymers for Drug Delivery and Study on Thermal Decomposition Kinetics

摘要

Magnetic targeting materials are the hot topic of research in the current study of targeted drug carrier. However, the complexity of the preparation method has hindered its further development. In this paper, a facile one-pot strategy was developed to synthesize a novel amphiphilic drug carrier (Fe3O4-PVA@SH). We determined that Fe3O4-PVA@SH drug carrier with uniform size and excellent superparamagnetic properties can be fabricated on the simultaneous formation of magnetic Polyvinyl alcohol(PVA) polymer-linked branches of thiohydrazide-iminopropyltriethoxysilane (TIPTS) by mixing Fe3O4, PVA, and TIPTS in a DMSO alkaline aqueous solution. The Fe3O4-PVA@SH drug carrier were subsequently characterised by FTIR, XPS, SEM, EDS, size and VSM. It was found that the drug carrier Fe3O4-PVA@SH could achieve 83% aspirin loading and 85% DOX?HCl loading. In vitro simulated drug release experi- ments showed that Aspirin could achieved 86.9% at pH 7.2 and DOX?HCl could achieved 81.6% at pH 4.7 for 80 h. Additionally, we measured the thermal stability and enthalpy of thermal decomposition of the Fe3O4-PVA@SH coupling agent using a differential scanning calorimeter (DSC) and a non-isothermal decomposition method. This research offers the potential for the industrialization of magnetic drug carriers as a means of increasing its cost-effectiveness and leveraging magnetic targeted drug carriers for drug delivery and other applications.