Excellent Catalytic Activity of Two Cd(II)Metal-Organic Frameworks in The Synthesis of Benzothiazolo-Pyrimidines

摘要

We report the noteworthy catalytic activity of two threedimensional, rigid and porous Metal-Organic Frameworks(MOFs)constructed from Cd(II)and 2,6-naphthalene dicarboxylic acid(2,6-ndc)ligand with different structural arrangements, namely [Cd3(2,6-ndc)3(DMF)4(NO3)]~-(1)and [Cd2(2,6-ndc)2(DMF)2](2)in organic synthesis. Excellent porosity and Lewis acidic/basic centres accrued in the structural arrangement rendered both superb catalyst characteristics. Both MOFs exhibited perfect catalytic activity for the one-pot fusion of chosen substituted benzaldehyde, malononitrile and 2-amino benzothiazol to synthesise medicinally valuable benzothiazolopyrimidine derivatives. Eight novel benzothiazolo-pyrimidines were generated with 92-96% yield in ethanol at room temperature with a short reaction time of 15-25 min. While both complexes showed excellent catalytic performance, MOF 1 exhibited superior activity due to more catalytic active sites. Overall, the protocol addressed the green approach to meet the conditions of green solvent, heterogeneity, catalyst repeatability up to six cycles, 98% atom economy and 100% carbon efficiency.