Design, Synthesis and Biological Evaluation of Tetrahydrodibenzo[b,g][1,8]napthyridinones as Potential Anticancer Agents and Novel Aurora Kinases Inhibitors

摘要

Aurora kinases inhibitors A and B have elucidated a vital role within the carcinogenesis and metastases of assorted sort of cancer. Variety of novel methodologies of drug style and support of potential enzyme inhibitors square measure listed in clinical trials, probably there‘s no advanced clinical role for kinases because the key targets for developing drug than in cancer medical care until date. Therefore, we have designed and synthesized novel tetrahydrodibenzo[b,g] [1,8] naphthyridinone molecules victimisation L-Proline in ethanol as associate adept organocatalyst for one-pot synthesis.