A New Boron 2-(2'-pyridyl) Imidazole Complex as a Candidate Photosensitizer for Photodynamic Therapy

摘要

In this work, different from the literature, boron 2-(2'-pyridyl) imidazole complex (BOPIM) was derived from pyridine ring side to extend π conjugation for the first time. In addition, the core of BOPIM was brominated to increase the capacity of singlet oxygen generation via intersystem crossing to function as a photosensitizer. According to photophysical measurements, the new BOPIM derivative had comparatively large Stokes shift as 111 nm among boron-fluorine derivatives in the literature. Its singlet oxygen generation potential and toxic effect in the dark were investigated in the presence of singlet oxygen trap 1,3-Diphenylisobenzofuran (DPBF). According to the obtained results, it was seen that the new BOPIM derivative could be a good photosensitizer for photodynamic therapy.