Vaspin regulated cartilage cholesterol metabolism through miR155/LXR alpha and participated in the occurrence of osteoarthritis in rats

He Hangyuan; Lu Mengting; Shi Huasong; Yue Guoping; Luo Hanwen

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Vaspin regulated cartilage cholesterol metabolism through miR155/LXR alpha and participated in the occurrence of osteoarthritis in rats

机译：Vaspin调节软骨胆固醇代谢通过MiR155 /LXRα，并参与大鼠骨关节炎的发生

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Aims: This study intends to explore the role of Vaspin and cholesterol metabolism in the process of osteoarthritis (OA) and its mechanism in vitro and in vivo.

机译：目的：本研究旨在探讨Vaspin和胆固醇代谢在骨关节炎（OA）发病过程中的作用及其体内外机制。

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来源
《Life sciences》 |2021年第1期|共9页
作者
He Hangyuan; Lu Mengting; Shi Huasong; Yue Guoping; Luo Hanwen;
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作者单位

Guangxi Med Univ Affiliated Hosp 4 Guangxi Liuzhou Workers Hosp Dept Joint Osteopathy Liuzhou;

Guangxi Med Univ Affiliated Hosp 4 Guangxi Liuzhou Workers Hosp Dept Joint Osteopathy Liuzhou;

Wuhan Univ Zhongnan Hosp Dept Orthoped Surg Wuhan 430071 Peoples R China;

Guangxi Med Univ Affiliated Hosp 4 Guangxi Liuzhou Workers Hosp Dept Joint Osteopathy Liuzhou;

Guangxi Med Univ Affiliated Hosp 4 Guangxi Liuzhou Workers Hosp Dept Joint Osteopathy Liuzhou;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Vaspin; Cholesterol metabolism; miR155; Cholesterol efflux pathway; Osteoarthritis;

机译：瓦斯平;胆固醇代谢;miR155;胆固醇外排途径;骨关节炎;

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1. Effects of endoplasmic reticulum stress in cartilage tissue of knee osteoarthritis on the secretion of inflammation molecules and bone metabolism molecules [J] . Qian-Kai Li, Rui-Hong Hu, Jiang-Mei Li 海南医科大学学报(英文版) . 2019,第010期
2. Effects of endoplasmic reticulum stress in cartilage tissue of knee osteoarthritis on the secretion of inflammation molecules and bone metabolism molecules [J] . Qian-Kai Li, Rui-Hong Hu, Jiang-Mei Li 海南医科大学学报（英文版） . 2019,第010期
3. Phosphoinositide-3-kinase regulatory subunit 4 participates in the occurrence and development of amyotrophic lateral sclerosis by regulating autophagy [J] . Yue Liu, Cai-Hui Wei, Cheng Li, 中国神经再生研究（英文版） . 2022,第007期
4. Study on the relationship between PI3K/AKT signaling pathway and apoptosis in cartilage tissue of rats with osteoarthritis [J] . Xiao-Yan Li, Yan Zhang, Chun-Ping Dong, 海南医科大学学报（英文版） . 2017,第011期
5. Persimmon tannin regulates the expression of genes critical for cholesterol absorption and cholesterol efflux by LXR alpha independent pathway [J] . Ge Zhenzhen, Zhu Wei, Peng Jinming, Journal of Functional Foods . 2016,第Null期

机译：柿单宁通过LXR alpha独立途径调节胆固醇吸收和胆固醇外流的关键基因的表达
6. Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis. [J] . Collins Racie LA, Yang Z, Arai M Osteoarthritis and cartilage . 2009,第7期

机译：人体骨关节炎关节软骨中核受体表达和失调的全局分析：降低的LXR信号传导有助于骨关节炎典型的分解代谢。
7. LXR modulation blocks prostaglandin E_2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model [J] . Ning Li, Moises A. Rivera-Bermudez, Mei Zhang, Proceedings of the National Academy of Sciences of the United States of America . 2010,第8期

机译：LXR调节剂可阻断前列腺素E_2的产生和软骨中基质的降解，并减轻大鼠骨关节炎模型的疼痛
8. Effects of Chronic Aluminum Exposure on the Collagen Metabolism of Bone and Cartilage in Rats: The Toxic Effects of Aluminum on Bone and Cartilage in Rats [C] . Li Xin-Wei, Zhang Li-Chao, Hu Chong-Wei, International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：慢性铝暴露对大鼠骨质和软骨胶原蛋白代谢的影响：铝对大鼠骨质和软骨的毒性作用
9. Regulatory networks of PXR, CAR and LXR in cholesterol and bile acid metabolism. [D] . Uppal, Hirdesh. 2007

机译：胆固醇和胆汁酸代谢中PXR，CAR和LXR的调控网络。
10. LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model [O] . Ning Li, Moisés A. Rivéra-Bermúdez, Mei Zhang, 2010

机译：LXR调节剂可阻断前列腺素E2的产生和软骨中基质的降解并减轻大鼠骨关节炎模型的疼痛
11. Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis [O] . Collins-Racie L.A., Yang Z., Arai M., 2009

机译：人体骨关节炎关节软骨中核受体表达和失调的整体分析LXR信号的减少有助于骨关节炎典型的分解代谢
12. The Kinetics of Excretion of Alpha-Aminoisobutyric Acid in Rats. Potential Use as an Indicator for Nitrogen Metabolism [R] . Metcalf, W. 1970

机译：大鼠α-氨基异丁酸排泄动力学研究。潜在用作氮代谢的指标

Vaspin regulated cartilage cholesterol metabolism through miR155/LXR alpha and participated in the occurrence of osteoarthritis in rats

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