Extracellular vesicles from GPNMB-modified bone marrow mesenchymal stem cells attenuate bone loss in an ovariectomized rat model

Huang Ba; Su Yongwei; Shen Enpu; Song Meng; Liu Danping; Qi Hui

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Extracellular vesicles from GPNMB-modified bone marrow mesenchymal stem cells attenuate bone loss in an ovariectomized rat model

机译：来自GPNMB改性的骨髓间充质干细胞的细胞外囊囊肿细胞在卵巢切除大鼠模型中衰减骨质损失

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摘要

Aims: The efficacy of anti-osteoporotic treatments is still limited. Our study aimed to investigate the effect of extracellular vesicles (EVs) derived from bone marrow-derived MSCs (BMSCs) overexpressing glycoprotein non-melanoma clone B (GPNMB) on osteoporosis (OP).

机译：目的：抗骨质疏松治疗的效果仍然有限。我们的研究旨在研究来源于骨髓间充质干细胞（BMSCs）的过度表达糖蛋白非黑色素瘤克隆B（GPNMB）的细胞外小泡（EV）对骨质疏松症（OP）的影响。

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来源
《Life sciences》 |2021年第1期|共15页
作者
Huang Ba; Su Yongwei; Shen Enpu; Song Meng; Liu Danping; Qi Hui;
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作者单位

Jinzhou Med Univ Dept Orthopaed Affiliated Hosp 1 Jinzhou 121000 Peoples R China;

Yixian Peoples Hosp Dept Orthopaed Yixian 121100 Peoples R China;

Jinzhou Med Univ Dept Orthopaed Affiliated Hosp 1 Jinzhou 121000 Peoples R China;

Jinzhou Med Univ Dept Orthopaed Affiliated Hosp 1 Jinzhou 121000 Peoples R China;

Jinzhou Med Univ Dept Orthopaed Affiliated Hosp 1 Jinzhou 121000 Peoples R China;

Beijing Jishuitan Hosp Beijing Res Inst Traumatol &

Orthopaed Beijing 100035 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Glycoprotein non-melanoma clone B; Extracellular vesicles; Mesenchymal stem cells; Osteogenesis; Osteoporosis;

机译：糖蛋白非黑色素瘤克隆B;细胞外小泡;间充质干细胞;成骨;骨质疏松症;

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1. Pre-treatment with bone marrow-derived mesenchymal stem cells inhibits systemic intravascular coagulation and attenuates organ dysfunction in lipopolysaccharide-induced disseminated intravascular coagulation rat model [J] . WANG Biao, WU Shu-ming, WANG Tao, 中华医学杂志（英文版） . 2012,第010期
2. Bone marrow mesenchymal stem cell transplantation combined with perindopril treatment attenuates infarction remodelling in a rat model of acute myocardial infarction [J] . WANG Jian-an, LUO Rong-hua, ZHANG Xing, 浙江大学学报（英文版）（B辑：生物医学和生物技术） . 2006,第008期
3. Bone marrow-derived mesenchymal stem cell transplantation attenuates overexpression of infiammatory mediators in rat brain after cardiopulmonary resuscitation [J] . Qing-Ming Lin, Xia-Hong Tang, Shi-Rong Lin, 中国神经再生研究（英文版） . 2020,第002期
4. Human bone marrow mesenchymal stem cell transplantation attenuates axonal injur y in stroke rats [J] . Yi Xu, Shiwei Du, Xinguang Yu, 中国神经再生研究（英文版） . 2014,第023期
5. Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model [J] . Zhengzhou Shi, Qi Wang, Youbo Zhang, Stem Cell Research & Therapy . 2020,第1期

机译：通过骨髓间充质干细胞产生的细胞外囊泡在UUO大鼠模型中抑制RhoA /岩石途径，部分骨髓间充质干细胞衰减肾纤维化。
6. Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats [J] . Sylwia Dabrowska, Anna Andrzejewska, Damian Strzemecki, Journal of neuroinflammation . 2019,第1期

机译：人骨髓间充质干细胞来源的细胞外囊泡减轻了大鼠局灶性脑损伤诱发的神经炎症
7. Bone marrow mesenchymal stem cells reduce ureteral stricture formation in a rat model via the paracrine effect of extracellular vesicles [J] . Jintai Luo, Shankun Zhao, Jiamin Wang, Journal of cellular and molecular medicine. . 2018,第9期

机译：骨髓间充质干细胞通过细胞外囊泡的旁分泌作用减少大鼠模型中输尿管狭窄的形成
8. Biomaterial-Mediated Delivery of Uncultured Rat Bone Marrow Mononuclear Cells and Culture-Expanded Mesenchymal Stem Cells for Large Bone Defect Healing [C] . Joel K Wise, Andrea I. Alford, Jan P. Stegemann Society for Biomaterials annual meeting and exposition . 2013

机译：生物材料介导的未培养的大鼠骨髓单核细胞和培养扩展的间充质干细胞用于大骨缺损愈合的传递
9. Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cell, but not Adipose Tissue-Derived Stem Cell, Ameliorated the Neonatal Hypoxic-Ischemic Brain Injury by Changing Cerebral Inflammatory State in Rat [D] . Sugiyama Yuichiro, 杉山裕一朗 2019

机译：静脉内施用骨髓源性间充质干细胞，而非脂肪组织源性干细胞，通过改变大鼠的脑炎症状态改善了新生儿缺氧缺血性脑损伤
10. Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis in part by inhibiting the RhoA/ROCK pathway in a UUO rat model [O] . Zhengzhou Shi, Qi Wang, Youbo Zhang, 2020

机译：通过骨髓间充质干细胞产生的细胞外囊泡在UUO大鼠模型中抑制RhoA /岩石途径部分骨髓间充质干细胞衰减肾纤维化。
11. Extracellular vesicles produced by bone marrow mesenchymal stem cells attenuate renal fibrosis, in part by inhibiting the RhoA/ROCK pathway, in a UUO rat model [O] . Zhengzhou Shi, Qi Wang, Youbo Zhang, 2020

机译：通过骨髓间充质干细胞产生的细胞外囊泡在UUO大鼠模型中抑制RhoA /岩石途径，部分骨髓间充质干细胞衰减肾纤维化。
12. Repair of Traumatic Skeletal Muscle Injury with Bone-Marrow-Derived Mesenchymal Stem Cells Seeded on Extracellular Matrix. [R] . Merritt, E. K., Cannon, M. V., Hammers, D. W., 2010

机译：骨髓间充质干细胞接种于细胞外基质修复创伤性骨骼肌损伤。

Extracellular vesicles from GPNMB-modified bone marrow mesenchymal stem cells attenuate bone loss in an ovariectomized rat model

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