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首页> 外文期刊>Annals of vascular surgery >One-year outcome after percutaneous rotational and aspiration atherectomy in infrainguinal arteries in patient with and without type 2 diabetes mellitus.
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One-year outcome after percutaneous rotational and aspiration atherectomy in infrainguinal arteries in patient with and without type 2 diabetes mellitus.

机译：患有和不患有2型糖尿病的患者在经皮动脉旋转和抽吸斑块旋切术后一年的结局。

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BACKGROUND: To compare the safety and efficacy of a rotational aspiration atherectomy system (Jetstream) for the treatment of infrainguinal arteries in diabetic versus nondiabetic patients. METHODS: A total of 172 patients with Rutherford stage 1-5 lower limb ischemia were treated with rotational aspiration atherectomy between February 2006 and February 2007. Of these, 80 patients with type 2 diabetes mellitus (DM: 46.5%) were compared with 92 nonDM (53.5%) patients. Overall, 210 target lesions (99 DM; 111 nonDM) were treated, located in the superficial femoral (67% DM; 61% nonDM), popliteal (25% DM; 30% nonDM), and tibial (8% DM; 9% nonDM) arteries. Lesion characteristics were comparable in both groups, mean lesion length was 28.5 mm (DM) and 26.2 mm (nonDM); total occlusions were present in 29% (DM) and 32% (nonDM), and 15% (DM) and 14% (nonDM) were restenotic. RESULTS: In the entire cohort, device success was 99% (all but two lesions). The major adverse event (MAE) rate (death, index limb amputation, myocardial infarction, target lesion revascularization [TLR] and target vessel revascularization) in DM at 30 days was 2.5% (n = 2 planned amputations) and 0% in nonDM. At 6 and 12 months, MAE in DM was seen in 13.8% (11/80) and 25% (20/80) compared with 21.7% (20/92) and 31.5% (29/92) in nonDM, respectively. TLR rate through 12 months was 20% (16/80) in DM and 28% in nonDM (26/92). Overall, 1 year restenosis rate was 38.2% based on duplex. The ankle-brachial index, mean Rutherford categories, and walking impairment questionnaire did not differ between groups at baseline and were increased significantly in both study cohorts at 12 months. CONCLUSION: Jetstream-assisted atherectomy in infrainguinal arteries is safe and effective in DM compared with nonDM patients. In this short-lesion cohort, vessel patency in diabetics was as good as for non-DM at 1 year. TLR and MAE were higher by trend in nonDM, although planned amputations were seen only in DM. The clinical benefit was similar in both groups.
机译：背景：为了比较安全性和有效性的旋转抽吸旋磨术系统（Jetstream）治疗糖尿病患者和非糖尿病患者的龈下动脉。方法：从2006年2月至2007年2月，对172例卢瑟福1-5期下肢缺血的患者进行了旋切术。其中80例2型糖尿病患者（DM：46.5％）与92例非DM患者进行了比较（53.5％）患者。总体而言，共治疗了210例靶病变（99例DM; 111例非DM），分别位于股浅表（67％DM; 61％nonDM），pop（25％DM; 30％nonDM）和胫骨（8％DM; 9％）。 nonDM）动脉。两组的病变特征相当，平均病变长度为28.5 mm（DM）和26.2 mm（nonDM）。总闭塞率为29％（DM）和32％（nonDM），再狭窄为15％（DM）和14％（nonDM）。结果：在整个队列中，设备成功率为99％（除两个病变以外的所有病变）。 DM在30天时的主要不良事件（MAE）发生率（死亡，食肢截肢，心肌梗塞，目标病变血运重建[TLR]和目标血管血运重建）为2.5％（n = 2计划的截肢），非DM为0％。在6和12个月时，DM中的MAE分别为13.8％（11/80）和25％（20/80），而非DM中分别为21.7％（20/92）和31.5％（29/92）。糖尿病患者至12个月的TLR率为20％（16/80），非糖尿病患者为28％（26/92）。总体而言，基于双工的1年再狭窄率为38.2％。基线时，两组之间的踝肱指数，平均卢瑟福类别和步行障碍调查表无差异，并且两个研究组在12个月时均显着增加。结论：与非DM患者相比，射流辅助下动脉在动脉粥样硬化中的安全性和有效性。在这一短病变队列中，糖尿病患者在1年时的血管通畅与非糖尿病患者一样。非计划生育者的TLR和MAE升高趋势更高，尽管计划切除者仅在糖尿病患者中见到。两组的临床获益相似。

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