Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder

摘要

Study Objectives: Idiopathic rapid eye movement sleep behavior disorder (iRBD), characterized by rapid eye movement sleep without atonia (RSWA) and dream-enactment behavior, has been suggested to be a predictor of alpha-synucleinopathies. Autonomic instability, represented by heart rate variability, is a common characteristic of both iRBD and alpha-synucleinopathies. Previous studies reported that RSWA was associated with autonomic dysfunction and was a possible predictor of phenoconversion. Therefore, we sought to compare heart rate variability between iRBD and control groups and explore the relationship between heart rate variability and RSWA in patients with iRBD.