Impact of Caffeine Boluses and Caffeine Discontinuation on Apnea and Hypoxemia in Preterm Infants

摘要

2 <88% and <75% were measured. Results: ABDs were analyzed in 302 preterm infants (mean gestational age 27.6 weeks) around the time of 485 serum caffeine levels, 90 caffeine boluses, and 273 episodes of caffeine discontinuation. Higher serum caffeine levels were not associated with fewer ABDs or higher heart rate. For caffeine boluses given due to clinically recognized spells, hypoxemia and algorithm-detected ABDs decreased day 1–2 after the bolus compared to the day before and day of the bolus (mean 4.4 events/day after vs. 6.6 before, p?=?0.004). After caffeine discontinuation, there was no change in hypoxemia and a small increase in ABDs (2 events/day 3–5 days after discontinuation vs. 1 event/day before and >5 days after, p?