EFFECTS OF HIGH-FREQUENCY OSCILLATORY VENTILATION AND PARTIAL LIQUID VENTILATION ON ACUTE LUNG INJURY INDUCED BY STEAM INHALATION IN NEW ZEALAND RABBITS

摘要

Objective: to investigate the beneficial effects of high-frequency oscillatory ventilation (HFOV) and partial liquid ventilation (PLV) in treating acute lung injury induced by steam inhalation Design: a prospective, randomized, controlled, multiple-group study Setting: an animal research centre laboratory in a university burns centre Subjects: New Zealand rabbits (n=30; 2.25 +- 0 25 kg) of either sex. Interventions: the animals were ventilated by HFOV with a mean airway pressure of 10 cm H_2O, a frequency of 10 Hz, an amplitude of 20 cm H_2O, an I:E ratio of 1:1, and an FiO_2 of 1 0 After the induction of acute lung injury by steam inhalation, the animals were randomly assigned to receive either HFOV alone or a combined therapy of HFOV + PLV The animals were grouped as HFOV, HFOV + PLV, and control group (without ventilation after recovery from muscular relaxation) Measurements and main results: arterial blood gases, cardiovascular haemodynamics, dynamic lung compliance, and total lung injury scores were measured After steam inhalation, all three groups displayed low PaO_2 and low dynamic lung compliance In the control group all the animals died within 3 h In the HFOV and HFOV + PLV groups, all the animals displayed significant improvements in dynamic lung compliance, oxygenation, and histological outcomes; HFOV + PLV showed the best results Conclusion: in a New Zealand rabbit model of steam inhalation injury, HFOV improved oxygenation, increased dynamic lung compliance, and alleviated lung histological injury Combined therapy with HFOV + PLV was clearly superior to that with HFOV alone during the observation period.