DIASTEREOSELECTIVE SYNTHESIS OF 5-IODOALKENYL-2-OXAZOLINES BY ELECTROPHILIC CYCLIZATION OF ALLENYL AMIDES

摘要

The electrophilic cyclization of allenyl amides is described. Allenyl amides were easily prepared from the propargyl aziridines via the [1,5]-hydrogen shift followed by the conversion of the imine moiety to the amides. 5-Iodoalkenyl-2-oxazolines having a variety of substituents were diastereoselectively obtained by the reaction of the allenyl amides with iodine.