ONE-POT AND EFFICIENT SYNTHESIS OF 5-AMINOPYRAZOLE-4-CARBONITRILES CATALYZED BY POTASSIUM PHTHALIMIDE

摘要

The potassium phthalimide (PPI) has been found to be an efficient, recyclable, inexpensive, commercially available, and easy to handle catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles through the one-pot, three-component reaction of easily available starting reactants involving aldehydes, phenylhydrazine, and malononitrile. This reaction was performed in a mixture of EtOH:H2O as a green reaction media at 50 degrees C. The catalyst could be recovered easily from the filtrate via evaporation of solvent and reused many times. The present eco-friendly three-component cyclo condensation offers main benefits including, time-saving, mild conditions, minimize the amount of waste, high atom efficiency, avoiding the hazardous organic solvents or catalysts, and the ease of the work-up.