Development of a new phantom simulating extracellular space of tumor cell growth and cell edema for diffusion-weighted magnetic resonance imaging

摘要

Objective A phantom for diffusion-weighted imaging is required to standardize quantitative evaluation.The objectives were to develop a phantom simulating various cell densities and to evaluate repeatability.Materials and methods The acrylic fine particles with three different diameters were used to simulate human cells.Fourdegree cell density components were developed by adjusting the volume of 10-μm particles (5,20,35,and 50% volume,respectively).Two-degree components to simulate cell edema were also developed by adjusting the diameter without changing number (17% and 40% volume,respectively).Spearman's rank correlation coefficient was used to find a significant correlation between apparent diffusion coefficient (ADC) and particle density.Coefficient of variation (CV) for ADC was calculated for each component for 6 months.A p value < 0.05 represented a statistically significance.Results Each component (particle ratio of 5,17,20,35,40,and 50% volume,respectively) presented ADC values of 1.42,1.30,1.30,1.12,1.09,and 0.89 (× 10~(?3) mm~2/s),respectively.A negative correlation (r = ? 0.986,p < 0.05) was observed between ADC values and particle ratio.CV for ADC was less than 5%.Discussion A phantom simulating the diffusion restriction correlating with cell density and size could be developed.