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Maternal antioxidant intake during pregnancy and the development of cows' milk allergy in the offspring

机译:孕产妇抗氧化剂在怀孕期间的摄入和后代奶牛牛奶过敏的发展

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Cows' milk allergy (CMA) is the most common food allergy in young children, and it is often the first manifestation of atopic diseases. Accordingly, very early environmental factors, such as maternal diet during pregnancy, may play a role in the development of CMA, but the evidence is limited. The aim of this study was to investigate the association between maternal intake of antioxidant nutrients during pregnancy and the subsequent development of CMA in the offspring in a prospective, population-based birth cohort within the Finnish Type 1 Diabetes Prediction and Prevention Study. Maternal dietary information during pregnancy was collected with a detailed, validated FFQ. The maternal dietary information and the information on putative confounding factors were available for 4403 children. Information on diagnosed CMA (n 448) was obtained from a medical registry and queried from the parents up to child's age of 3 years. The Finnish food composition database was used to calculate the average daily intake of nutrients. Logistic regression was applied for statistical analyses, and the nutrient intakes were adjusted for energy intake. OR are presented per 1 sd increment of the particular nutrient intake. Maternal total and dietary intake of beta-carotene was associated with an increased risk of CMA in the offspring when adjusted for the putative confounding factors (total OR 1 center dot 10, 95 % CI 1 center dot 02, 1 center dot 20; dietary OR 1 center dot 10; 95 % CI 1 center dot 01, 1 center dot 19). Using dietary supplements containing antioxidants in addition to a balanced diet may not confer any additional benefits.
机译:牛奶过敏(CMA)是幼儿最常见的食物过敏,通常是特应性疾病的第一表现。因此,非常早期的环境因素,如孕期母亲的饮食,可能在CMA的发展中发挥作用,但证据有限。本研究的目的是在芬兰1型糖尿病预测和预防研究的一个前瞻性、基于人群的出生队列中,调查孕期母亲摄入抗氧化营养素与后代CMA后续发展之间的关系。孕期母亲的饮食信息是通过详细、有效的FFQ收集的。4403名儿童可获得母亲膳食信息和假定的混杂因素信息。关于诊断出的CMA(N448)的信息是从医学登记处获得的,并从儿童3岁以下的父母那里查询。芬兰食物成分数据库用于计算每日营养素的平均摄入量。采用逻辑回归进行统计分析,并根据能量摄入调整营养素摄入量。或以特定营养素摄入量的1 sd增量表示。当调整假定的混杂因素(总或1中心点10,95%可信区间1中心点02,1中心点20;膳食或1中心点10;95%可信区间1中心点01,1中心点19)时,母体β-胡萝卜素的总摄入量和膳食摄入与子代患CMA的风险增加相关。除了均衡饮食之外,使用含有抗氧化剂的膳食补充剂可能不会带来任何额外的好处。

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