The clinical severity score of chronic actinic dermatitis correlates with in vivo photoallergic reactions and the immunologic parameters related to a shift towards Th2 immunity from the Th2/Th1 balanced status in patients with chronic actinic dermatitis

摘要

Background Chronic actinic dermatitis (CAD) has a more complicated pathogenetic basis than others. The clinical grading system and its correlations with the clinical and immunological parameters still remained to be investigated to define the nature of CAD in a more detailed manner. Objectives We investigated correlations of the clinical severity score of CAD (CSS-CAD) with the clinical and immunological parameters. Methods We evaluated 72 patients with CAD and classified them into three groups according to the CSS-CAD. We analysed total IgE level, peripheral blood (PB) eosinophil count, the ratio of Th2cell (CCR4 + CD4 +) percentage over Thl cell (CXCR3 + CD4 +) percentage (Th2/Thl) and/or the sum of suppressor/cytotoxic T cells. Results The total IgE levels and the percentage of PB eosinophils were higher in the severer group than other groups. A shift towards Th2 from Th2/Thl balanced status may be affected by total counts of suppressor T cells, and the patient with higher Th2/Thl ratio than balanced status had the more proportion in the severer CSS-CAD group than other groups. Conclusion The CSS-CAD correlates with total IgE level, PB eosinophil count and a shift towards Th2 immunity from Th2/Thl. So we suggest the Thl/Th2 dysbalance may be affected by the CSS-CAD.