Comparison of the Intraocular Pressure-Lowering Effect and Safety of Preservative-Free And Preservative-Containing Brimonidine/Timolol Fixed-Combination Ophthalmic Solutions in Patients with Open-Angle Glaucoma

Kim Joon Mo; Kim Tae-Woo; Park Sang-Woo; Park Hae-Young Lopilly; Hwang Young Hoon; Jeoung Jin Wook; Kim Chan Yun

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Comparison of the Intraocular Pressure-Lowering Effect and Safety of Preservative-Free And Preservative-Containing Brimonidine/Timolol Fixed-Combination Ophthalmic Solutions in Patients with Open-Angle Glaucoma

机译：在开放角度荧光眼患者中对含防腐剂和防腐剂的吡尼尼胺/蒂莫尔固定组合的眼科溶液的疗效降低效应和安全性的比较

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Purpose: To compare the therapeutic efficacy and safety of newly developed preservative-free (PF) brimonidine/timolol fixed-combination (BTFC) ophthalmic solutions and a preservative-containing (PC) BTFC ophthalmic solution in patients with open-angle glaucoma.

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来源
《Seminars in ophthalmology》 |2021年第3期|共7页
作者
Kim Joon Mo; Kim Tae-Woo; Park Sang-Woo; Park Hae-Young Lopilly; Hwang Young Hoon; Jeoung Jin Wook; Kim Chan Yun;
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作者单位

Sungkyunkwan Univ Sch Med Kangbuk Samsung Hosp Dept Ophthalmol Seoul South Korea;

Seoul Natl Univ Coll Med Bundang Hosp Dept Ophthalmol Seongnam South Korea;

Chonnam Natl Univ Med Sch &

Hosp Dept Ophthalmol Gwangju South Korea;

Catholic Univ Korea Seoul St Marys Hosp Dept Ophthalmol Coll Med Seoul South Korea;

Chungnam Natl Univ Hosp Dept Ophthalmol Daejeon South Korea;

Seoul Natl Univ Dept Ophthalmol Seoul Natl Univ Hosp Coll Med Seoul South Korea;

Yonsei Univ Coll Med Inst Vis Res Dept Ophthalmol Severance Hosp Seoul South Korea;

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原文格式 PDF
正文语种 eng
中图分类眼科学;
关键词
Open-angle glaucoma; intraocular pressure; brimonidine; timolol fixed combination; preservative-free; normal-tension glaucoma;

机译：开放角青光眼;眼压;吡蒙胺胺;蒂莫尔固定组合;无保存;普通张力青光眼;

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专利

1. Safety and efficacy of bimatoprost/timolol fixed combination in Chinese patients with open-angle glaucoma or ocular hypertension [J] . Ling Zhihong, Zhang Mingchang, Hu Yizhen, 中华医学杂志（英文版） . 2014,第005期
2. Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma [J] . Murat, Atabey, Ozer, 国际眼科杂志：英文版 . 2014,第005期
3. Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma [J] . Murat, Atabey, Ozer, 国际眼科杂志：英文版 . 2014,第005期
4. A Phase III Randomized Clinical Trial of a 0.5% Timolol?+?0.2% Brimonidine?+?2.0% Dorzolamide Fixed Combination, Preservative-Free Ophthalmic Solution vs. 0.5% Timolol?+?0.2% Brimonidine?+?2.0% Dorzolamide Fixed Combination in Patients with Controlled Primary Open-Angle Glaucoma [J] . Francisco Gómez-Aguayo, José A. Paczka, Rubén Le?ero-Córdova, Ophthalmology and therapy. . 2018,第1期

机译：0.5％Timolol？+？0.2％Brimonidine？+？2.0％Dorzolamide固定组合，无防腐剂眼药液与0.5％Timolol？+？0.2％Brimonidine？+？2.0％Dorzolamide固定组合的III期随机临床试验原发性开角型青光眼的控制
5. Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol-dorzolamide combination. [J] . Akman A, Cetinkaya A, Akova YA, Eye . 2005,第2期

机译：拉坦前列素和溴莫尼定在原发性开角型青光眼患者中，噻吗洛尔-多佐胺联合用药不能控制的眼压降低效果比较。
6. Comparison of the intraocular pressure-lowering effect and safety of brimonidine/timolol fixed combination and 0.5 % timolol in normal-tension glaucoma patients [J] . Kim Joon Mo, Kim Tae-Woo, Kim Chan Yun, Japanese Journal of Ophthalmology . 2016,第1期

机译：溴莫尼定/替莫洛固定组合和0.5％替莫洛在正常血压青光眼患者眼内降压效果和安全性比较
7. Efficacy Analysis of Preservative-Free Tafluprost and Timolol in Open-Angle Glaucoma and OHT Patients in a Phase-III Study [C] . GrundenJ., Lupinacci R. International Symposium on Ocular Pharmacology and Therapeutics . 2013

机译：在第三阶段研究中，在开放角度荧光眼和OHT患者中无防腐型TaFluprost和蒂莫尔的疗效分析
8. A Phase III Randomized Clinical Trial of a 0.5 Timolol + 0.2 Brimonidine + 2.0 Dorzolamide Fixed Combination Preservative-Free Ophthalmic Solution vs. 0.5 Timolol + 0.2 Brimonidine + 2.0 Dorzolamide Fixed Combination in Patients with Controlled Primary Open-Angle Glaucoma [O] . Francisco Gómez-Aguayo, José A. Paczka, Rubén Leñero-Córdova, 2018

机译：在控制原发性开角度的患者中采用0.5％Timolol + 0.2％溴莫尼定+ 2.0％Dorzolamide固定组合无防腐剂眼药液与0.5％Timolol + 0.2％溴莫尼定+ 2.0％Dorzolamide固定组合的三阶段随机临床试验。青光眼
9. Comparison of the Intraocular Pressure-Lowering Effect and Safety of Preservative-Free And Preservative-Containing Brimonidine/Timolol Fixed-Combination Ophthalmic Solutions in Patients with Open-Angle Glaucoma [O] . Joon Mo Kim, Tae-Woo Kim, Sang-Woo Park, 2021

机译：在开放角度荧光眼患者中对含有无防腐剂和防腐剂的吡尼尼胺/蒂莫尔固定组合的眼科溶液的眼内降低效应和安全性的比较

Comparison of the Intraocular Pressure-Lowering Effect and Safety of Preservative-Free And Preservative-Containing Brimonidine/Timolol Fixed-Combination Ophthalmic Solutions in Patients with Open-Angle Glaucoma

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