Reports of novel microanostructures designed to separate biomacromolecules and bioparticles are increasing in number, and these studies have greatly advanced our understanding of nanoscale fluidics and nanoparticle behavior in confined channels. This review is aimed at summarizing previous developments in microanofabricated systems for nanoparticle separations. These are discussed in three groups based on architecture, namely, microanopillar array structures, nanoplane gap structures and artificial nanoporous membranes.
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