Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

摘要

Abstract Background & Aims Non‐invasive assessment methods for liver fibrosis are urgently needed. The present study aimed to develop a novel diagnostic model for fibrosis staging in patients with chronic hepatitis B. Methods A cross‐sectional set of 417 chronic hepatitis B patients who underwent liver biopsy was enrolled and the METAVIR score was adopted as the reference of fibrosis staging. Results Among thyroid hormones, only the level of free tetraiodothyronine ( FT 4) decreased gradually with the METAVIR fibrosis score ( P? ? .001). FibroStage, a novel diagnosis model that incorporates data on FT 4, platelets, cholinesterase, gamma‐glutamyl transpeptidase, and age, was developed using the deriving set (n?=?219). For the diagnosis of significant fibrosis, the FibroStage model had a significantly higher area under the receiver operating curve than did the FibroIndex, Forn, and Lok models (all of P? ? .01) and tended to better than the fibrosis‐4 ( P? = ? .0791) but comparable with the aspartate transaminase‐to‐platelet ratio index model ( P? = ? .1694). For the diagnosis of advanced fibrosis, FibroStage had a higher area under the receiver operating curve than did the aspartate transaminase‐to‐platelet ratio index, FibroIndex, Forn, and Lok models (all of P? ? .05) and had a comparable area under the receiver operating curve with the fibrosis‐4 model ( P? = ? .2109). For the diagnosis of cirrhosis, the area under the receiver operating curve of FibroStage was higher than those of the aspartate transaminase‐to‐platelet ratio index, fibrosis‐4, FibroIndex, and Lok (all of P? ? .05) models and was comparable with Forn ( P? = ? .1649). These results was validated by a validation set (n?=?198). Conclusion FT 4 may be an indicator for fibrosis staging in chronic hepatitis B patients. FibroStage is a better model than aspartate transaminase‐to‐platelet ratio index, fibrosis‐4, FibroIndex, Forn, and Lok for the comprehensively diagnosis of significant and advanced fibrosis and cirrhosis.