Molecular cytogenetic findings supporting the evidence of a biclonal origin in acute myeloid leukemia.

摘要

Hematologic malignancies are clonal disorders arising from a single mutated cell. However, the detection of more than one cytogenetically unrelated abnormal clone has occasionally been reported . Cytogenetic biclonality has rarely been observed in adult acute myeloid leukemia (AML); in none of the cases reported in literature has a molecular cytogenetic analysis been performed [1, 5]. We report a case of adult AML-M2 at diagnosis with biclonal cytogenetic abnormalities represented by two novel translocations. The first clone showed a translocation t(l;2)(p23;p21), while in the second clone, we observed an unbalanced t(ll;12)(q!3;pl3).