The role of the cholinergic anti-inflammatory pathway in septic cardiomyopathy

摘要

Septic cardiomyopathy (SCM) is common in septic patients and results in cardiovascular failure. The pathogenesis of SCM is complicated, and patients with SCM have high mortality because current treatment methods are limited. The cholinergic anti-inflammatory pathway (CAP) modulates inflammatory responses through vagus nerve stimulation that leads to the release of acetylcholine (ACh), which binds to the alpha7 nicotinic acetylcholine receptor (alpha 7nAChR). Moreover, alpha 7nAChR activation by its agonists at the tissue level inhibits inflammatory mediators and regulates the function of immune cells in sepsis. Therefore, the alpha 7nAChR can maintain balance of the inflammatory-immune response in sepsis. CAP has been elucidated as a critical regulator of anti inflammation in many diseases, including rheumatoid arthritis, inflammatory bowel disease and SCM. Additionally, some clinical and preclinical trials show therapeutic potential via regulating CAP. There are excellent studies regarding the beneficial role of CAP activation, especially alpha 7nAChR, in experimental SCM. This review aims to discuss the CAP in attenuating inflammation and the potential role of alpha 7nAChR activation in regulating immune and reducing inflammation in SCM.