Stereoselective synthesis of C1-C11 fragment of antitumor cyclodepsipeptide (-)-doliculide

摘要

A general and stereoselective synthetic route for C1-C11 polyketide fragment of doliculide has been achieved in an efficient manner. The key reactions of our synthetic route are enzymatic desymmetrization of meso-diol, application of Evans auxiliary to introduce methyl group, Sharpless asymmetric epoxidation and substrate controlled nucleophilic addition reactions.