Fully automatic segmentation of sinonasal cavity and pharyngeal airway based on convolutional neural networks

摘要

Introduction: This study aimed to test the accuracy of a new automatic deep learning-based approach on the basis of convolutional neural networks (CNN) for fully automatic segmentation of the sinonasal cavity and the pharyngeal airway from cone-beam computed tomography (CBCT) scans. Methods: Forty CBCT scans from healthy patients (20 women and 20 men; mean age, 23.37 +/- 3.34 years) were collected, and manual segmentation of the sinonasal cavity and pharyngeal subregions were carried out by using Mimics software (version 20.0; Materialise, Leuven, Belgium). Twenty CBCT scans from the total sample were randomly selected and used for training the artificial intelligence model file. The remaining 20 CBCT segmentation masks were used to test the accuracy of the CNN fully automatic method by comparing the segmentation volumes of the 3-dimensional models obtained with automatic and manual segmentations. The accuracy of the CNN-based method was also assessed by using the Dice score coefficient and by the surface-to-surface matching technique. The intraclass correlation coefficient and Dahlberg's formula were used to test the intraobserver reliability and method error, respectively. Independent Student t test was used for between-groups volumetric comparison. Results: Measurements were highly correlated with an intraclass correlation coefficient value of 0.921, whereas the method error was 0.31 mm(3). A mean difference of 1.93 +/- 0.73 cm(3) was found between the methodologies, but it was not statistically significant (P>0.05). The mean matching percentage detected was 85.35 +/- 2.59 (tolerance 0.5 mm) and 93.44 +/- 2.54 (tolerance 1.0 mm). The differences, measured as the Dice score coefficient in percentage, between the assessments done with both methods were 3.3% and 5.8%, respectively. Conclusions: The new deep learning-based method for automated segmentation of the sinonasal cavity and the pharyngeal airway in CBCT scans is accurate and performs equally well as an experienced image reader.