Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

Wagh Kshitij; Hahn Beatrice H.; Korber Bette

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Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

机译：击中甜点：利用HIV-1 Glycan屏蔽诱导宽度中和抗体

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Purpose of review

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来源
《Current opinion in HIV and AIDS》 |2020年第5期|共8页
作者
Wagh Kshitij; Hahn Beatrice H.; Korber Bette;
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作者单位

Los Alamos Natl Lab T 6 Theoret Biol &

Biophys Los Alamos NM USA;

Univ Penn Dept Med Philadelphia PA 19104 USA;

Los Alamos Natl Lab T 6 Theoret Biol &

Biophys Los Alamos NM USA;

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原文格式 PDF
正文语种 eng
中图分类产科学;
关键词
broadly neutralizing antibodies; glycan shield; HIV-1 vaccines;

机译：宽度中和抗体;甘油盾;HIV-1疫苗;

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1. N-terminal residues of an HIV-1 gp41 membrane-proximal external region antigen influence broadly neutralizing 2F5-like antibodies [J] . Dezhi Li, Jie Liu, Li Zhang, 中国病毒学：英文版 . 2015,第006期
2. Antigen Gene Cloning and Expression of HIV-1 for AIDS Vaccine Design Ⅲ. HIV-1 Antigen Gene Cloning, in Vitro Expression and Antibody Induction [J] . ZENG Qingping(曾庆平), FENG Liling(冯丽玲), YANG Ruiyi(杨瑞仪), 中华性传播感染杂志（英文版） . 2002,第003期
3. Chinks in the armor of the HIV-1 Envelope glycan shield: Implications for immune escape from anti-glycan broadly neutralizing antibodies [J] . Moyo Thandeka, Ferreira Roux-Cil, Davids Reyaaz, Virology . 2017,第期

机译：HIV-1封套甘草盾的盔甲中的爆裂：对免疫逃逸的影响免受抗甘草的广泛中和抗体
4. Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies [J] . J Julien, L Kong, R Pejchal, Retrovirology . 2012,第S2期

机译：有效的广泛中和抗体对HIV-1 Env聚糖盾的识别和渗透
5. Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies [J] . J Julien, L Kong, R Pejchal, Retrovirology . 2012,第S2期

机译：有效的广泛中和抗体对HIV-1 Env聚糖盾的识别和渗透
6. Structure-Guided Engineering of Broadly Neutralizing Antibodies Targeting the CD4 Binding Site of HIV-1 Envelope [C] . Yen-Ting Lai, Qingbo Liu, Peng Zhang, Protein Engineering Summit. . 2018

机译：靶向靶向HIV-1包络CD4结合位点的宽度中和抗体的结构引导工程
7. Broadly Neutralizing Antibodies and Broadly Neutralizing Sera: Insights into HIV-1 Vaccine Design [D] . Walker, Laura M. 2011

机译：广泛中和抗体和广泛中和血清：对HIV-1疫苗设计的见解
8. Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies [O] . J Julien, L Kong, R Pejchal, 2012

机译：有效的广泛中和抗体对HIV-1 Env聚糖盾的识别和渗透
9. Recognition and penetration of the HIV-1 Env glycan shield by potent broadly neutralizing antibodies [O] . J Julien, L Kong, R Pejchal, 2013

机译：有效的广泛中和抗体对HIV-1 Env聚糖盾的识别和渗透
10. Plaque Transfer Assay for Detecting Neutralizing Antibodies to HTLV-III (AIDS). HIV-1 Inactivation by Antibodies: Predominance of a Group-Specific Epitope that Persists Despite Genetic Variation [R] . Berkower, I., Murphy, D. 1989

机译：用于检测HTLV-III（aIDs）的中和抗体的噬斑转移测定。抗体的HIV-1灭活：尽管存在遗传变异，但仍然存在的群特异性表位的优势

Hitting the sweet spot: exploiting HIV-1 glycan shield for induction of broadly neutralizing antibodies

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