High-resolution pediatric reference intervals for 15 biochemical analytes described using fractional polynomials

摘要

Objectives: Assessment of children's laboratory test results requires consideration of the extensive changes that occur during physiological development and result in pronounced sex- and age-specific dynamics in many biochemical analytes. Pediatric reference intervals have to account for these dynamics, but ethical and practical challenges limit the availability of appropriate pediatric reference intervals that cover children from birth to adulthood. We have therefore initiated the multi-center data-driven PEDREF project Next-Generation Pediatric Reference Intervals) to create pediatric reference intervals using data from laboratory information systems.