Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study

Norquist Barbara M.; Brady Mark F.; Harrell Maria I.; Walsh Tom; Lee Ming K.; Gulsuner Suleyman; Bernards Sarah S.; Casadei Silvia; Burger Robert A.; Tewari Krishnansu S.; Backes Floor; Mannel Robert S.; Glaser Gretchen; Bailey Cheryl; Rubin Stephen; Soper John; Lankes Heather A.; Ramirez Nilsa C.; King Mary Claire; Birrer Michael J.; Swisher Elizabeth M.

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Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study

机译：GOG 218中卵巢癌患者同源重组基因和结果的突变：NRG肿瘤学/妇科肿瘤学群体研究

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Purpose: We hypothesized that mutations in homologous recombination repair (HRR) genes beyond BRCA1 and BRCA2 improve outcomes for ovarian carcinoma patients treated with platinum therapy and would impact the relative benefit of adding prolonged bevacizumab.

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《Clinical cancer research: an official journal of the American Association for Cancer Research》 |2018年第4期|共7页
作者
Norquist Barbara M.; Brady Mark F.; Harrell Maria I.; Walsh Tom; Lee Ming K.; Gulsuner Suleyman; Bernards Sarah S.; Casadei Silvia; Burger Robert A.; Tewari Krishnansu S.; Backes Floor; Mannel Robert S.; Glaser Gretchen; Bailey Cheryl; Rubin Stephen; Soper John; Lankes Heather A.; Ramirez Nilsa C.; King Mary Claire; Birrer Michael J.; Swisher Elizabeth M.;
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作者单位

Univ Washington Div Gynecol Oncol Seattle WA 98195 USA;

Roswell Pk Canc Ctr Inst NRG Oncol Stat &

Data Ctr Buffalo NY USA;

Univ Washington Div Gynecol Oncol Seattle WA 98195 USA;

Univ Washington Dept Med Div Med Genet Seattle WA 98195 USA;

Univ Washington Dept Med Div Med Genet Seattle WA 98195 USA;

Univ Washington Dept Med Div Med Genet Seattle WA 98195 USA;

Univ Washington Div Gynecol Oncol Seattle WA 98195 USA;

Univ Washington Dept Med Div Med Genet Seattle WA 98195 USA;

Univ Penn Div Gynecol Oncol Philadelphia PA 19104 USA;

Univ Calif Irvine Div Gynecol Oncol Orange CA 92668 USA;

Ohio State Univ Med Ctr Div Gynecol Oncol Columbus OH 43210 USA;

Univ Oklahoma Div Gynecol Oncol Oklahoma City OK USA;

Mayo Clin Div Gynecol Surg Rochester MN USA;

Minnesota Oncol Div Gynecol Oncol Minneapolis MN USA;

Fox Chase Canc Ctr Dept Surg Oncol Div Gynecol Oncol 7701 Burholme Ave Philadelphia PA 19111;

Univ N Carolina Div Gynecol Oncol Chapel Hill NC USA;

Nationwide Childrens Hosp Res Inst Dept Pathol &

Lab Med Columbus OH USA;

Nationwide Childrens Hosp Res Inst Dept Pathol &

Lab Med Columbus OH USA;

Univ Washington Dept Med Div Med Genet Seattle WA 98195 USA;

Univ Alabama Birmingham Div Hematol Oncol Birmingham AL 35294 USA;

Univ Washington Div Gynecol Oncol Seattle WA 98195 USA;

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正文语种 eng
中图分类肿瘤学;
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1. The mutational pattern of homologous recombination (HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer [J] . Yue Fan, Lan Zheng, Haifeng Ying, 癌症生物学与医学（英文版） . 2020,第004期
2. The mutational pattern of homologous recombination(HR)-associated genes and its relevance to the immunotherapeutic response in gastric cancer [J] . Yue Fan, Haifeng Ying, Xueying Wu, 癌症生物学与医学：英文版 . 2020,第004期
3. Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs [J] . Mo Li, Juan Carlos Izpisua Belmonte, Keiichiro Suzuki, 细胞研究（英文版） . 2011,第012期
4. Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study [J] . Norquist Barbara M., Brady Mark F., Harrell Maria I., Clinical cancer research: an official journal of the American Association for Cancer Research . 2018,第4期

机译：GOG 218中卵巢癌患者在同源重组基因和结果中的突变：NRG肿瘤学/妇科肿瘤学群体研究
5. Neurotoxicity in ovarian cancer patients on Gynecologic Oncology Group (GOG) protocol 218: Characteristics associated with toxicity and the effect of substitution with docetaxel: An NRG Oncology/Gynecologic Oncology Group study [J] . Chase Dana M., Huang Helen, Foss Cassandra D., Gynecologic Oncology: An International Journal . 2015,第2期

机译：妇科肿瘤学组（GOG）方案218对卵巢癌患者的神经毒性：与毒性相关的特征以及多西他赛的替代作用：NRG肿瘤/妇科肿瘤学组研究
6. Risk Factors for Readmission in Patients With Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma Who Are Receiving Front-line Chemotherapy on a Clinical Trial (GOG 218): An NRG Oncology/Gynecologic Oncology Group Study (ADS-1236) EDITORIAL COMMENT [J] . Van Le Linda Obstetrical and gynecological survey . 2016,第1期

机译：在临床试验中接受一线化疗的卵巢癌，输卵管癌和原发性腹膜癌患者再次入院的危险因素（GOG 218）：NRG肿瘤/妇科肿瘤学组研究（ADS-1236）编辑评论
7. Sodium selenite in gynecologic radiation oncology. Results of a phase III study [C] . Muecke R., Glatzel M., Riesenbeck D., Workshop on Macro, Trace and Ultratrace Elements . 2004

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8. Ensemble Learning for Predicting Gynecological Oncology Patients Using Travel Distance [D] . Jarett, Jamie. 2019

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9. Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: an NRG Oncology/Gynecologic Oncology Group Study [O] . Barbara M. Norquist, Mark F. Brady, Maria I. Harrell, -1

机译：GOG 218中卵巢癌患者同源重组基因的突变和结果：NRG肿瘤/妇科肿瘤小组研究
10. A phase II evaluation of sunitinib in the treatment of persistent or recurrent clear cell ovarian carcinoma: An NRG Oncology/Gynecologic Oncology Group Study (GOG-254) [O] . John K. Chan, William Brady, Bradley J. Monk, 2018

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11. STUDIES ON MECHANISMS OF MUTATION, RECOMBINATION, AND GENE ACTION IN NEUROSPORA [R] . Norman H. Giles 1975

机译：神经鞘膜突变，重组和基因作用机制的研究

Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study

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