Identification of Wild-Type Transthyretin Cardiac Amyloidosis by Quantifying Myocardial Extracellular Volume Using Cardiac Computed Tomography in Atrial Arrhythmias

摘要

Atrial arrhythmias (AAr), which includes atrial fibrillation and atrial flutter, are the most prevalent types of cardiac arrhythmia. AAr is associated with considerable morbidity and mortality, particularly in patients with heart failure. Recent studies have suggested that up to 10% to 15% of older adults with heart failure may have unrecognized wild-type transthyretin cardiac amyloidosis (ATTRwt-CA). Moreover, ATTRwt-CA is often accompanied by AAr. Although treatment for ATTRwt-CA was previously limited to supportive care, pharmacological treatments of ATTRwt-CA are now available. The availability of new therapies potentially improves the prognosis of patients with ATTRwt-CA and AAr. However, using current diagnostic strategies, it is difficult to identify the occurrence of ATTRwt-CA in AAr patients before treatment.