Norlabdane Compounds Containing Thiosemicarbazone or 1,3-Thiazole Fragments: Synthesis and Antimicrobial Activity

摘要

New di-, tri-, tetra-, and pentanorlabdane compounds with thiosemicarbazone and 1,3-thiazole fragments were synthesized. Their antifungal and antibacterial activities were studied. The main advantages of this research were the available starting material, i.e., the natural labdane diterpenoid (-)-sclareol, which was isolated from renewable resources, and the high probability of biological activity combined with the low toxicity of these compounds because of their natural origin.