A New Phenolic Glycoside with Aldose Reductase Inhibitory Activity from Eucommia ulmoides

摘要

A new phenolic glycoside 1 and three known compounds (2-4) have been isolated from the 95% ethanolic extract of Eucommia ulmoides Oliv. leaves. Their structures were identified as erythro-1-O-methyl-2-O-beta-D-glucopyranosyl-guaiacylglycerol (1), 3,5-dimethoxybenzyl alcohol 4-O-beta-D-glucopyranoside (2), salidroside (3), and dihydroconiferin (4) from spectroscopic data (H-1 NMR, C-13 NMR, HSQC, and HMBC) and using chemical methods. In the in vitro assay, compound 1 displayed potent inhibitory activity against aldose reductase with an IC50 value of 7.82 mu M.