Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis

Zhang Minyi; Zhang Tao; Song Chenglin; Qu Jiao; Gu Yanpin; Liu Songjun; Li Haibo; Xiao Wei; Kong Lingdong; Sun Yang; Lv Wen

首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis

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Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis

机译：桂芝茯苓胶囊通过促进p62-keap1-nrf2介导的硬质裂解来改善子宫内膜增生

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摘要

Ethnopharmacological relevance: Guizhi Fuling Capsule (GFC) is a classical traditional Chinese medicine officially recorded in Synopsis of the Golden Chamber and has long been used to treat gynecological diseases in China. However, scientific evidence for the anti-endometrial hyperplasia potential of GFC used in traditional medicine is lacking.

机译：民族药理学相关性：桂枝茯苓胶囊（GFC）是《金匮要略》中正式记载的一种经典中药，在中国长期用于治疗妇科疾病。然而，缺乏科学证据证明GFC在传统医学中具有抗子宫内膜增生的潜力。

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来源
《Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs》 |2021年第1期|共10页
作者
Zhang Minyi; Zhang Tao; Song Chenglin; Qu Jiao; Gu Yanpin; Liu Songjun; Li Haibo; Xiao Wei; Kong Lingdong; Sun Yang; Lv Wen;
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作者单位

Tongde Hosp Zhejiang Prov Dept Gynecol 234 Gucui Rd Hangzhou 310012 Peoples R China;

Nanjing Univ Sch Life Sci Dept Biotechnol &

Pharmaceut Sci State Key Lab Pharmaceut Biotechnol;

Nanjing Univ Sch Life Sci Dept Biotechnol &

Pharmaceut Sci State Key Lab Pharmaceut Biotechnol;

Nanjing Univ Sch Life Sci Dept Biotechnol &

Pharmaceut Sci State Key Lab Pharmaceut Biotechnol;

Tongde Hosp Zhejiang Prov Dept Gynecol 234 Gucui Rd Hangzhou 310012 Peoples R China;

Tongde Hosp Zhejiang Prov Dept Gynecol 234 Gucui Rd Hangzhou 310012 Peoples R China;

Jiangsu Kan Pharmaceut Co Ltd Lianyungang 222001 Jiangsu Peoples R China;

Jiangsu Kan Pharmaceut Co Ltd Lianyungang 222001 Jiangsu Peoples R China;

Nanjing Univ Sch Life Sci Dept Biotechnol &

Pharmaceut Sci State Key Lab Pharmaceut Biotechnol;

Nanjing Univ Sch Life Sci Dept Biotechnol &

Pharmaceut Sci State Key Lab Pharmaceut Biotechnol;

Tongde Hosp Zhejiang Prov Dept Gynecol 234 Gucui Rd Hangzhou 310012 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Guizhi Fuling Capsule; Endometrial hyperplasia; Ferroptosis; GPX4; NRF2;

机译：GUI中if U领capsule;en dome trial hyper PL Asia;F err op to思思;GP X4;n RF2;

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1. Effect of Guizhi Fuling Capsule on sex hormone level and tumor markers in patients with uterine fibroids [J] . Juan-Juan Zhao, Fu-Juan Guan 海南医科大学学报(英文版) . 2018,第016期
2. Effect of Guizhi Fuling Capsule on sex hormone level and tumor markers in patients with uterine fibroids [J] . Juan-Juan Zhao, Fu-Juan Guan 海南医科大学学报（英文版） . 2018,第016期
3. Effect of Guizhi Fuling capsules in combined with mifepristone on treatment of adenomyosis [J] . Yu-Xiang Fan 海南医科大学学报（英文版） . 2015,第012期
4. Evaluation of Anti-Inflammatory Components of Guizhi Fuling Capsule, an Ancient Chinese Herbal Formula, in Human Umbilical Vein Endothelial Cells [J] . Yuzhong Zheng, Guizhong Xin, Guowei Gong, Evidence-based complementary and alternative medicine: eCAM . 2020,第9期

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5. Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity [J] . Weiran Zheng, Meng Li, Yongxiang Wang, Evidence-based complementary and alternative medicine: eCAM . 2020,第9期

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6. An integrative urinary metabolomic study of the therapeutic effect of Guizhi Fuling capsule on primary dysmenorrheal rats based H-1 NMR and UPLC-MS [J] . Xiong Zhili, Lang Lang, Gao Xun, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2019,第期

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7. Texture Segmentation of Endometrial Images for Aiding Diagnosis of Hyperplasia [C] . Sharif, B., Ahmadian, . 2005

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8. Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer [D] . Wohlhieter, Corrin A. 2021

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9. Deciphering the Pharmacological Mechanisms of Guizhi-Fuling Capsule on Primary Dysmenorrhea Through Network Pharmacology [O] . Siqin Zhang, Xinxing Lai, Xin Wang, 2021

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10. Simultaneous determination of seven bioactive components in Guizhi Fuling capsule by microwave-assisted extraction combined with ultra performance liquid chromatography tandem mass spectrometry [O] . Yang Sui, Long-Shan Zhao, Zhen-Zhong Wang, 2015

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11. Etiology and Effects of Ciomiphene on Cystic Endometrial Hyperplasia in the Miniature Pig. [R] . Dutta, C. 1986

机译：Ciomiphene对小型猪囊性子宫内膜增生的病因及影响。

Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis

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