A facile synthesis of mono-dispersed, spherical and mesoporous bioactive glass nanoparticles for biomedical applications

摘要

Bioactive glasses (BG) have become a popular class of biomaterials for a range of medical applications due to their enhanced dissolution rate, cell internalization capability and ionic dissolution products with therapeutic benefits. Here, we introduce, for the first time, a simplified synthesis procedure in order to create nanoparticles with uniform, spherical and mesoporous BG structure with a ternary composition of SiO2-CaO-P2O5. The hydroxyapatite forming ability is also evaluated to confirm the bioactivity. Doxorubicin, a model drug, is loaded within BG nanoparticles with an encapsulation efficiency was 35%. Cytotoxicity evaluations confirmed the nontoxic nature of the nanoparticles when exposed to MG63 cell line. Overall, results suggest the diverse orthopedic and dental application of mesoporous bioactive glass (MBG) nanoparticles.