首页> 外国专利> A PROCESS FOR POLYETHYLENIMINE AND ORGANIC REDUCING AGENT -MEDIATED SYNTHETIC INSERTION OF GOLD NANOPARTICLES WITHIN MESOPOROUS SILICA NANOPARTICLES AND THEIR BIOMEDICAL APPLICATIONS

A PROCESS FOR POLYETHYLENIMINE AND ORGANIC REDUCING AGENT -MEDIATED SYNTHETIC INSERTION OF GOLD NANOPARTICLES WITHIN MESOPOROUS SILICA NANOPARTICLES AND THEIR BIOMEDICAL APPLICATIONS

机译:介孔二氧化硅纳米粒子中聚乙烯亚胺和有机还原剂介导的金纳米粒子的合成插入及其生物医学应用

摘要

Mesoporous silica nanoparticles (MSNP) with control over pore size and nanogeometry can be used as an efficient and safe carrier for drug delivery and biocatalysis. The surface modification of such MSNPs using suitable reagent may provide a robust framework in which two or more components can be incorporated to give multifunctional capabilities specifically synthesis of noble metal nanoparticles within mesoporous architecture along with specific loading of bioactive molecule. We report herein the polyethylenimine (PEI) and formaldehyde mediated synthesis of gold nanoparticles in mesoporous architecture of silica nanoparticles using; (a) unmodified MSNP and (b) 3-trihydroxysilylpropyl methylphosphonate modified MSNPs. The finding on these lines demonstrated the following; (i) PEI enable synthetic incorporation of gold nanoparticles in the presence of formaldehyde in both unmodified and modified MSNP, (ii) An increase in PEI concentration results relative increase in the nanogeometry of gold nanoparticles during synthetic incorporation in MSNP, (iii) phosphonate modified MSNP yielded into relatively better nanogeomtery of AuNPs, (iv) Unmodified MSNP resulted with an increase in polycrystalline behavior of AuNPs (v) the catalytic activity of AuNPs incorporated within modified MSNP are better as compared to that recorded with unmodified MSNP. The MSNPs of average size of 200 nm with pore size between 4-6 are used for AuNPs synthesis. It has been found that PEI coating enable AuNPs synthesis within mesopores in the presence of formaldehyde or tetrahydrofuran hydroperoxide between 10-25 oC or at 60oC even in absence of organic reducing agents. AuNPs incorporated MSNP shows efficient biocatalyst as peroxidase mimetic. In addition to that paclitaxel can also be loaded in AuNPs modified MSNP justifying novelty in drug delivery. The AuNPs incorporated within mesoporous matrix have been characterized by transmission electron microscopy, EADX and HR SEM. The cationic polymer coating enhances the electrocatalytic performances of nanoparticles justifying potentiality for safe delivery of drug.
机译:具有控制孔径和纳米几何形状的介孔二氧化硅纳米粒子(MSNP)可以用作药物输送和生物催化的有效和安全载体。使用合适的试剂对此类MSNP进行表面修饰可以提供一个稳固的框架,其中可以结合两个或多个组件以提供多功能功能,特别是介孔结构内贵金属纳米颗粒的合成以及生物活性分子的特定负载。我们在此报道了使用聚乙烯亚胺(PEI)和甲醛介导的二氧化硅纳米颗粒的介孔结构中金纳米颗粒的合成。 (a)未修饰的MSNP和(b)3-三羟基甲硅烷基丙基甲基膦酸酯修饰的MSNP。这些方面的发现证明了以下几点: (i)PEI能够在甲醛存在下在未改性和改性MSNP中合成掺入金纳米颗粒,(ii)PEI浓度的增加导致在MSNP合成掺入过程中金纳米颗粒的纳米几何相对增加,(iii)膦酸酯改性MSNP产生了相对更好的AuNPs纳米晶体,(iv)未经修饰的MSNP导致AuNPs的多晶行为增加(v)与未经修饰的MSNP相比,修饰的MSNP中掺入的AuNPs的催化活性更好。平均大小为200 nm,孔径在4-6之间的MSNP用于AuNPs合成。已经发现,在10-25oC或60oC之间存在甲醛或四氢呋喃氢过氧化物的情况下,即使不存在有机还原剂,PEI涂层也可以在中孔内合成AuNPs。结合了AuNPs的MSNP显示了作为过氧化物酶模拟物的有效生物催化剂。除此以外,紫杉醇还可以装载在AuNPs修饰的MSNP中,从而证明了药物输送的新颖性。通过透射电子显微镜,EADX和HR SEM对掺入介孔基质中的AuNPs进行了表征。阳离子聚合物涂层增强了纳米颗粒的电催化性能,证明了安全递送药物的潜力。

著录项

  • 公开/公告号IN201611042267A

    专利类型

  • 公开/公告日2018-04-27

    原文格式PDF

  • 申请/专利权人

    申请/专利号IN201611042267

  • 发明设计人 PREM CHANDRA PANDEY;GOVIND PANDEY;

    申请日2016-12-11

  • 分类号A61K47;

  • 国家 IN

  • 入库时间 2022-08-21 12:52:18

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