Solute-solvent interactions of ibuprofen in the aqueous solutions of 1-propanol: Volumetric, acoustic and viscometric study

摘要

Ternary system contains ibuprofen + water +1-propanol in the certain composition have been reported as forming two phases systems. Therefore solute-solvent and solute-solute interactions are necessary for a fundamental understanding of the phase equilibrium in this ternary system. In this work solute-solvent and solute-solute interactions were studied via volumetric, acoustic and viscometric methods. The experimental densities, speed of sounds and viscosities of ibuprofen in mixtures of water + -propanol with different cosolvent proportions (w(1-pro) = 1.000, w(1-pro )= 0.950, w(1-pro) = 0.900, w(1-pro) = 0.850, w(1-pro) = 0.800) were measured at temperatures T = 288.15, 298.15 and 308.15 K. The apparent molar volume (V-phi), apparent molar volume at infinite dilution (V-phi(o)), apparent molar volume of transfer (Delta V-tr(phi)o). apparent molar isentropic compressibility (kappa(phi)), apparent molar isentropic compressibility at infinite dilution (kappa(o)(phi)) and viscosity B-coefficient were calculated using the experimental data. The obtained apparent molar volume, apparent molar isentropic compressibility at infinite dilution and viscosity B-coefficient are explained in terms of solute-solvent and solute-solute interactions.The obtained results reveal that solute-solvent interactions decrease with increasing temperature. Also, solute-solvent interactions decrease with decreasing weight fraction of 1-propanol. This behavior may be due to preferential solvation of ibuprofen with 1-propanol. (C) 2020 Elsevier B.V. All rights reserved.